pMEV2HA-HRAS-S17N

Human Ha-Ras Xpress Clones Ras proteins are members of small GTPase superfamily. They bind GDP/GTP and possess intrinsic GTPase activity. These proteins act as switches to turn on/off their downstream target proteins in response to upstream stimuli because they can alternate between an inactive form bound to GDP and an active form bound to GTP. Activating mutations of HRAS, including G12V, activate the potential of HRAS to transform cultured cells and are implicated in a variety of human tumors. Defects in HRAS are also the cause of oral squamous cell carcinomas (oscc). S17N is a widely used dominant negative mutant of HRAS.Gene Name: Homo sapiens v-Ha-ras Harvey rat sarcoma viral oncogene homolog. Other Names: HRAS1, RASH1, Ha-Ras - 20 ug