pMEV2HA-AKT1-K179A

pMEV2HA-AKT1-K179A is a mammalian expression vector encoding a kinase-inactive mutant of human AKT1, where the critical catalytic residue Lysine 179 (K179) is substituted with alanine (K179A). This mutation disrupts ATP binding, rendering the kinase functionally inactive. Equipped with an N-terminal HA tag, this clone allows easy detection and is widely used to study AKT1-dependent signaling pathways, cell survival mechanisms, and dominant-negative effects in various cell models. Ideal for researchers investigating the PI3K/AKT pathway, signal inhibition, and functional genomics. - 20 ug